Do the 5 Axis Breakout Board with Relay requires software to setup

The breakout board does not require software to run, specifically. The breakout board serves only as a signal conditioner where the input signal from the computer is output at the corresponding terminal, or the terminal receives a signal and is conditioned and sent to the parallel connector to be read by the computer. As long as the software can communicate to the parallel port of the computer, then the breakout board will function.