I have not come across this problem, but there may be USB, or firmware issues that you are experiencing. I would recommend going on the polabs website and using their support center (https://support.poscope.com/)and posing that question to them. Also, have you tried the ethernet port as an alternative to see if that helps?
Here is the response from an LLM:
Check USB Cable and Port: Start with the basics. Sometimes this error is due to a poor USB connection. Ensure you're using a high-quality, shielded USB cable and that it's plugged into a USB port directly on your computer, not through a hub. If possible, try a different USB port or a different cable to rule out any issues there.
Update Firmware and Software: Ensure that both your PoKeys57CNC firmware and the Mach4 software are up to date. Firmware updates for your PoKeys board might include optimizations or fixes that address connectivity issues.
USB Polling Rate: This error can also arise from the USB polling rate setting in the PoKeys configuration software. It might be set too high for your system's ability to handle it. Try lowering the polling rate and see if that resolves the error.
Computer Performance: Check your computer’s performance. If it’s running several heavy applications simultaneously, it might not be able to process signals from the PoKeys board fast enough. Try closing unnecessary applications or consider using a dedicated machine if your current setup is too taxed.
Mach 4 and PoKeys Plugin Configuration: Dive into the Mach 4 plugin configuration for PoKeys. Ensure that all settings are correctly configured as per the manual. Incorrect settings might lead to communication bottlenecks.
Connection Quality and Interference: Consider any potential interference sources near your CNC setup or computer. Electromagnetic interference from large motors, other electronics, or long cable runs can affect communication quality. Try rearranging your setup to minimize interference.
Consult Documentation and Support: If the issue persists, consult the detailed documentation provided by PoKeys or reach out to their customer support. They can offer more specific advice based on the latest product updates or known issues.
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I HAVE FOLLOWED YOUR YOUTUBE VIDEO ON SETTING UP THE POKEYS 57CNC BOARD BUT WHEN OPEN MACH 4 GET A ERROR MESSAGE CONNECTION IS TO SLOW